Publications
Zachary W. Hoisington, Himanshu Gangal, Khanhky Phamluong, Chhavi Shukla, Yann Ehinger, Jeffrey J. Moffat, Gregg E. Homanics, Jun Wang, and Dorit Ron. Prosapip1 in the dorsal hippocampus mediates synaptic protein composition, long-term potentiation, and spatial memory. J Neurosci. 2024 Jul 17. 44 (29) doi: 10.1523/JNEUROSCI.1644-23.2024
Zachary W. Hoisington, Alexandra Salvi, Sophie Laguesse, Yann Ehinger, Chhavi Shukla, Khanhky Phamluong, Dorit Ron. The small G-protein Rac1 in the dorsomedial striatum promotes alcohol-dependent structural plasticity and goal-directed learning in mice. Journal of Neurosciences 2024. In Press. BioRXiv
Yann Ehinger, Sophie Laguesse, Khanhky Phamluong, Alexandra Salvi, Zachary W. Hoisington, Drishti Soneja, Yoshitaka J. Sei, Ken Nakamura, Dorit Ron. Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Mice Consuming Alcohol Attenuates Glycolysis. bioRxiv 2023 doi: https://doi.org/10.1101/2023.11.29.569312
Yann Ehinger, Khanhky Phamluong, Dorit Ron. Sex Differences In The Interaction Between Alcohol And mTORC1. bioRxiv 2023 doi: https://doi.org/10.1101/2023.10.04.560781
Daniel da Silva, Aya Matsui, Erin M. Murray, Adamantios Mamais, Michael E. Authement, Jung Hoon Shin, Marlisa Shaw, Dorit Ron, Mark R. Cookson & Veronica A. Alvarez. Leucine-rich repeat kinase 2 limits dopamine D1 receptor signaling in striatum and biases against heavy persistent alcohol drinking. Neuropsychopharmacology. 2023 Sep 8. doi:10.1038/s41386-023-01731-z
Yann Ehinger, Drishti Soneja, Khanhky Phamluong, Alexandra Salvi, Dorit Ron. Identification of Novel BDNF-Specific Corticostriatal Circuitries. 2023. eNeuro 10(5). doi:10.1523/ENEURO.0238-21.2023.
Jefrey J. Mofat, Samuel A. Sakhai, Zachary W. Hoisington, Yann Ehinger, Dorit Ron. The BDNF Val68Met polymorphism causes a sex specifc alcohol preference over social interaction and also acute tolerance to the anxiolytic efects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice. 2023. Psychopharmacology (Berl)
. 2023 Jan 9. doi: 10.1007/s00213-022-06305-3.
. 2023 Jan 9. doi: 10.1007/s00213-022-06305-3.
Gabor Egervari, Cody A. Siciliano, Ellanor L. Whiteley, Dorit Ron. Alcohol and the brain: from genes to circuits. Trends Neurosci. 2021 Oct 23;S0166-2236(21)00187-9. doi: 10.1016/j.tins.2021.09.006.
Yann Ehinger, Ziyang Zhang, Khanhky Phamluong, Drishti Soneja, Kevan M. Shokat, Dorit Ron. Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice. 2021. Nature Communications volume 12, Article number: 4407.
Dual-Drug Therapy Shows Promise for Treating Alcohol Use Disorder
UCSF News July 30, 2021
Dual-Drug Therapy Shows Promise for Treating Alcohol Use Disorder
UCSF News July 30, 2021
Lindsay P. Cameron, Robert J. Tombari, Ju Lu, Alexander J. Pell, Zefan Q. Hurley, Yann Ehinger, Maxemiliano V. Vargas, Matthew N. McCarroll, Jack C. Taylor,Douglas Myers-Turnbull5, Tao hui Liu, Bianca Yaghoobi, Lauren J. Laskowski, Emilie I. Anderson, Guoliang Zhang, Jayashri Viswanathan, Brandon M. Brown, Michelle Tjia, Lee E. Dunlap, Zachary T. Rabow, Oliver Fiehn, Heike Wulff, John D. McCorvy, Pamela J. Lein, David Kokel, Dorit Ron, Jamie Peters, Yi Zuo, David E. Olson. A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature, 2021 Jan;589(7842):474-479. https://doi.org/10.1038/s41586-020-3008-z.
Portelli J., Farokhnia M., Deschaine S.L., Battista J.T, Lee M.R., Li X., Ron D., Leggio L. Investigating the link between serum concentrations of brain-derived neurotrophic factor and behavioral measures in anxious alcohol-dependent individuals. Alcohol. 2020 Aug 13;S0741-8329(20)30253-6. doi: 10.1016/j.alcohol.2020.07.009.
Ehinger Y, Morisot N, Sakhai S.A., Phamluong K, Adrover M.F., Alvarez V.A., Ron D. cAMP-Fyn signaling in the dorsomedial striatum direct pathway drives excessive alcohol use. Neuropsychopharmacology. 2020 May 17. doi: 10.1038/s41386-020-0712-1.
Ehinger Y, Phamluong K, Darevesky D, Welman M, Moffat J, Sakhai SA, Whiteley EL, Berger AL, Laguesse S, Farokhnia M, Leggio L, Lordkipanidzé M and Ron D. Differential Correlation of Serum BDNF and microRNA Content in Rats with Rapid or Late Onset of Heavy Alcohol Use. Addict Biol. 2020 Mar 5:e12890. doi: 10.1111/adb.12890. [Epub ahead of print]
Morisot N, Phamluong K, Ehinger Y, Berger AL, Moffat J, Ron D. mTORC1 in the Orbitofrontal Cortex Promotes Habitual Alcohol Seeking. Elife. 2019 Dec 11;8. pii: e51333. doi: 10.7554/eLife.51333.
Morisot N, Berger AL, Phamluong K, Cross A, Ron D. The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking. Addict Biol. Nov;24(6):1227-1234, 2019.
Dobbs LK, Kaplan AR, Bock R, Phamluong K, Shin JH, Bocarsly ME, Eberhart L, Ron D, Alvarez VA. D1 receptor hypersensitivity in mice with low striatal D2 receptors facilitates select cocaine behaviors. Neuropsychopharmacology. Mar;44(4):805-816, 2019.
Haun HL, Griffin WC, Lopez MF, Solomon MG, Mulholland PJ, Woodward JJ, McGinty JF, Ron D, Becker HC. Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice. Neuropharmacology. Sep 15;140:35-42, 2018.
Ben Hamida S, Laguesse S, Morisot N, Park J-H, Phuamluong K, Berger AL, Park KD and Ron D. mTORC1 and its downstream effector CRMP2 drive reinstatement of alcohol reward. Addiction Biol. 2018 Jul 18. doi: 10.1111/adb.12653.
Ron D, Berger A.Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders. Psychopharmacology June 2018, Volume 235, Issue 6, pp 1727–1743.
Vandenberg A, Lin WC, Tai L-H, Ron D, Wilbrecht L. Mice engineered to mimic a common Val66Met polymorphism in the BDNF gene show greater sensitivity to reversal in environmental contingencies. Dev Cogn Neurosci. Nov;34:34-41, 2018.
Barak S, Ahmadiantehrani S, Logrip ML, Ron D. GDNF and alcohol use disorder. Addict Biol. May;24(3):335-343, 2019.
Bird, C, Baculis, B, Mayfield, J, Chavez, G, Ontiveros, T, Paine, D, Marks, A, Gonzales, A, Ron, D, Valenzuela, C. The BDNF Val68Met polymorphism modulates how developmental ethanol exposure impacts the hippocampus. Genes Brain Behav. Mar;18(3):e12484, 2019.
Blegen M, da Silva E Silva DA, Bock R, Morisot N, Ron D, Alvarez V. Alcohol operant self-administration: Investigating how alcohol seeking behaviors predicts drinking in mice using two operant approaches. Alcohol. 2018 Mar;67:23-26. doi: 10.1016/j.alcohol.2017.08.008.
Morisot N, Novotny C.J., Shokat KM and Ron D. A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice. Addiction Biol. 2018 Mar;23(2):713-722. doi: 10.1111/adb.12528.
Laguesse S, Morisot N, Phamluong K, Sakhai SA, Ron D. mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption. Neuropsychopharmacology. Jun;43(7):1539-1547, 2018.
Laguesse S, Morisot N, Phamluong K, Ron D. Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents. Addict Biol. 2017 Nov;22(6):1856-1869. doi: 10.1111/adb.12464.
Laguesse S, Morisot N, Shin JH, Liu F, Adrover MF, Sakhai SA, Lopez MF, Phamluong K, Griffin III WC, Becker HC, Bender KJ, Alvarez VA, Ron D. Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Neuron. 2017 Sep 27;96(1):145-159.
Blocking Protein’s Action Causes Mice to Abandon ‘Problem Drinking, UCSF Study Finds
Commentary: E. Barbier, Heillig M. mTORC and ProSAPiP1: How Alcohol Changes Synapses of Reward Circuitry
Neuron 2017 Sept 27;96(1):6-8.
F1000 Prime Recommended
Medical News Today 12 Sept 2017
Blocking Protein’s Action Causes Mice to Abandon ‘Problem Drinking, UCSF Study Finds
Commentary: E. Barbier, Heillig M. mTORC and ProSAPiP1: How Alcohol Changes Synapses of Reward Circuitry
Neuron 2017 Sept 27;96(1):6-8.
F1000 Prime Recommended
Medical News Today 12 Sept 2017
Phamluong K, Darcq E, Wu S, Sakhai S, Ron D. Fyn Signaling Is Compartmentalized To Dopamine D1 Receptor Expressing Neurons In The Dorsal Medial Striatum. Frontiers Molecular Neuroscience. 31 August 2017.
Rinetti G, Phamluong K, Ron D, Bender KJ. Periadolescent maturation of GABAergic hyperpolarization at the axon initial segment. Cell Reports. Cell Rep. 2017 Jul 5;20(1):21-29.
Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW.Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res. 2017 Feb;41(2):345-358.
Wegner SA, Pollard KA, Kharazia V, Darevsky D, Perez L, Roychowdhury S, Xu A, Ron D, Nagy LE, Hopf FW.Limited Excessive Voluntary Alcohol Drinking Leads to Liver Dysfunction in Mice. Alcohol Clin Exp Res. 2017 Feb;41(2):345-358.
Liu F., Laguesse S., Legastelois R., Morisot N., Ben Hamida S. and Ron D. mTORC1-dependent Translation of Collapsin Response Mediator Protein-2 Drives Neuroadaptations Underlying Excessive Alcohol Drinking Behaviors. Mol Psychiatry. 2017 Jan;22(1):89-101. F1000Prime Recommended
Morisot N, Ron D. Alcohol-Dependent Molecular Adaptations of the NMDA Receptor System. Genes Brain Behav. 2017 Jan;16(1):139-148. doi: 10.1111/gbb.12363.
Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, and Ron D. The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. J. Neurosci. 2016, 36(39):10116-10127.
Neasta J, Fiorenza A, He D-Y, Phamluong K, Kiely PA, Ron D. Activation of the cAMP Pathway Induces RACK1-Dependent Binding of β-Actin to BDNF Promoter. PLoS One. 2016 Aug 9;11(18):e0160948.
Beckley J.T., Laguesse S., Phamluong K., Morisot N., Wegner S.A., and Ron D. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity In Nucleus Accumbens Dopamine D1 Receptor Neurons. J. Neurosci. 2016, 36(3): 701-713.
Ron D. and Barak S. Molecular mechanisms underlying alcohol-drinking behaviors. Nature Reviews Neuroscience. 17, 576–591, 2016.
Beckley JT and Ron D. Molecules to Medicine with mTOR. Elsevier Academic Press. 2016. 215-226.
Beckley JT and Ron D. Molecules to Medicine with mTOR. Elsevier Academic Press. 2016. 215-226.
Wang J, Cheng Y, Wang X, Hellard ER, Ma T, Gil H, Ben Hamida S, and Ron D. Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum. J. Neurosci. 2015; 35(33): 11634-11643.
This Week in The Journal
Editor’s Choice Sci Transl. Med.
This Week in The Journal
Editor’s Choice Sci Transl. Med.
Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. The Bdnf Val68 to Met Polymorphism Increases Compulsive Alcohol Drinking In Mice Which Is Reversed By TrkB Activation. Biol Psychiatry. 2016 Mar 15;79(6):463-73.
F1000Prime Recommended
Commentary: Pandey SC. A Critical Role of Brain-Derived Neurotrophic Factor in Alcohol Consumption.
Biol Psychiatry. 2016 Mar 15;79(6):427-9.
F1000Prime Recommended
Commentary: Pandey SC. A Critical Role of Brain-Derived Neurotrophic Factor in Alcohol Consumption.
Biol Psychiatry. 2016 Mar 15;79(6):427-9.
Darcq E, Warnault V, Phamluong K, Besserer GM, Liu F, Ron D. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Mol Psychiatry. 2015 Oct;20(10):1261.
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Barak S, Wang J, Ahmadiantehrani S, Ben Hamida S, Kells AP, Forsayeth J, Bankiewicz KS, Ron D. Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse. Addict Biol. 2015 Jul;20(4):629-4.
Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D. Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking. PLoS One. 2015 May 20;10(5):e0127408.
Logrip ML, Barak S, Warnault V, Ron D. Corticostriatal BDNF and alcohol addiction. Brain Res. 2015 Mar 21. pii: S0006-8993(15)00221-8.
Neasta J, Barak S, Ben Hamida S, Ron D. mTOR Complex 1: A Key Player in Neuroadaptations Induced by Drugs of Abuse. J Neurochem. 2014 Jul;130(2):172-84.
Ahmadiantehrani S, Barak S, Ron D.GDNF is a novel ethanol-responsive gene in the VTA: implications for the development and persistence of excessive drinking. Addict Biol. 2014 Jul;19(4):623-33.
Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D. Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking. PLoS One. 2015 May 20;10(5):e0127408.
Logrip ML, Barak S, Warnault V, Ron D. Corticostriatal BDNF and alcohol addiction. Brain Res. 2015 Mar 21. pii: S0006-8993(15)00221-8.
Neasta J, Barak S, Ben Hamida S, Ron D. mTOR Complex 1: A Key Player in Neuroadaptations Induced by Drugs of Abuse. J Neurochem. 2014 Jul;130(2):172-84.
Ahmadiantehrani S, Barak S, Ron D.GDNF is a novel ethanol-responsive gene in the VTA: implications for the development and persistence of excessive drinking. Addict Biol. 2014 Jul;19(4):623-33.
Darcq E, Ben Hamida S, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D. Inhibition of Striatal-enriched Tyrosine Phosphatase 61 in the Dorsomedial Striatum is Sufficient to Increase Ethanol Consumption. J Neurochem. 2014 Jun;129(6):1024-34.
Carnicella S, Ron D, Barak S. Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol. 2014 May;48(3):243-52.
Warnault V, Ron D. Chromatin remodeling: a new landscape to treat harmful alcohol-use disorders. Future Med Chem. 2013 Nov;5(17):2011-3.
Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, and Ron D. Protein Tyrosine Phosphatase {alpha} in the Dorsomedial Striatum Promotes Excessive Ethanol-Drinking Behaviors J. Neurosci. 2013;33 14369-14378
Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA. RACK(1) to the future - a historical perspective. Cell Commun Signal. 2013 Aug 1;11(1):53.
Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug;16(8):1094-100.
Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci. 2013 Aug;16(8):1111-7.
Jeanblanc J, Logrip ML, Janak PH, Ron D. BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. Eur J Neurosci. 2013 Feb;37(4):607-12.
Warnault V, Darcq E, Levine A, Barak S, Ron D. Chromatin remodeling - a novel strategy to control excessive alcohol drinking.Transl Psychiatry. 2013 Feb 19;3:e231.
Ahmadiantehrani S, Ron D. Dopamine D2 Receptor Activation Leads To An Upregulation Of Glial Cell Line-Derived Neurotrophic Factor Via Gβγ-Erk1/2-Dependent Induction Of Zif268. J Neurochem 2013 Apr;125(2):193-204.
Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res. 2013 Jan;37(1):8-15.
Ron D. and Messing RO. Signaling pathways mediating alcohol effects. In: Current Topics in Behavioral Neuroscience-Behavioral Neurobiology of Alcohol Addiction. Spanagel and Sommer (eds), Springer-Verlag, Heidelberg. Current Topics in Behavioral Neurosciences, 2013, Volume 13, 87-126.
Ben Hamida S., Neasta J., Lasek A.W., Kharazia V., Zou M., Carnicella S., Janak P.H., Ron D. The Small G Protein H-Ras in the Mesolimbic System Is a Molecular Gateway to Alcohol-Seeking and Excessive Drinking Behaviors. J. Neurosci. 2012;32 15849-15858. F1000 Prime Recommended, UCSF Press Release.
Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S, and Ron D. Ethanol-Mediated Facilitation of AMPA Receptor Function in the Dorsomedial Striatum: Implications for Alcohol Drinking Behavior. J. Neurosci. 2012;32 15124-15132.
Neasta J, Kiely PA, He D-Y, Adams DR, O'Connor R and Ron D. Direct interaction between scaffolding proteins RACK1 and 14-3-3{zeta} regulates brain-derived neurotrophic factor (BDNF) transcription. J. Biol. Chem. 2012; 287(1): p. 322-336.
Barak S, Ahmadiantehrani S, Kharazia V and Ron D. Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. Transl Psychiatry (2011) 1: e60.
Adams DR, Ron D, Kiely PA. RACK1, A Multifaceted Scaffolding Protein: Structure and Function. Cell Commun Signal. 2011 Oct 6;9(1):22.
Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ. Striatal Involvement in Human Alcoholism and Alcohol Consumption, and Withdrawal in Animal Models. Alcohol Clin Exp Res. 2011 Oct;35(10):1739-1748.
Gibb SL, Ben Hamida S, Lanfranco MF and Ron D. Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of PTPα. J Neurochem. 2011 Oct 11.
Barak S., Carnicella S., Yowell Q.V., Ron D. Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking. J.Neurosci. 2011 July 6;31 9885-9894
Neasta J, Ben Hamida S, Yowell QV, Carnicella S and Ron D. AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biological Psychiatry. Biol Psychiatry. 2011 Sep 15;70(6):575-82.
Wang J., Lanfranco M. F., Gibb S. L., Ron D. Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum. Channels (Austin). 2011 May-June;5(3);205-209.
Nie H., Rewal M., Gill T. M., Ron D. and Janak P. H. Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. PNAS 2011 Feb 22.
Gibb S. L., Jeanblanc J., Barak S., Yowell Q. V., Yaka R. and Ron D. Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward. J. Neurosci. 2011, Feb 9; 31(6):2180–2187.
Carnicella S., Yowell Q. and Ron D. Regulation of Operant Oral Ethanol Self-Administration: A Dose–Response Curve Study in Rats. Alcoholism: Clinical and Experimental Research. 35(1): 2011.
Neasta J., Hamida S., Yowell Q., Carnicella S. and Ron D. Role for Mammalian Target of Rapamycin Complex 1 Signaling in Neuroadaptations Underlying Alcohol-Related Disorders. Proceedings of the National Academy of Sciences. 107(46): p. 20093–20098, 2010. Supporting Information.
Wang J., Carnicella S., He D.Y., Ahmadiantehrani S., Barak S., Ben Hamida S., Kharazia V., Zapata A, Shippenberg T.S. and Ron D. Nucleus Accumbens-Derived GDNF Is a Retrograde Enhancer of Dopaminergic Tone in the Mesocorticolimbic System. J. Neurosci. 2010, Oct 27; 30 14502-14512.
Wang J., Lanfranco M.F., Gibb S.L., Yowell Q.V., Carnicella S., Ron D. Long-Lasting Adaptations of the NR2B-containing NMDA Receptors in the Dorsomedial Striatum Play a Crucial Role in Alcohol Consumption and Relapse. J. Neurosci. 2010, July 28; 30 10187-10198.
Carnicella S., He D-Y, Yowell Q.V., Glick S.D. and Ron D. Noribogaine, but not 18-MC, Exhibits Similar Actions as Ibogaine on GDNF Expression and Ethanol Self-Administration. Addiction Biology, 2010, Oct 6; 15(4), 424-433.
He, D-Y, Neasta, J and Ron, D. Epigenetic regulation of BDNF expression via the scaffolding protein RACK1. J Biol Chem. 2010 Jun 18;285(25):19043-50.
Jeanblanc J, He D-Y, Carnicella S, Kharazia V, Janak PH, Ron D. Endogenous BDNF in the Dorsolateral Striatum Gates Alcohol Drinking. J. Neurosci. 2009, Oct 28;29(43):13494-3502.
Logrip, M.L., Janak, P.H., and Ron, D. Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H. Alcohol. 2009 Aug;43(5):359-365.
Carnicella S, Ahmadiantehrani S, He DY, Nielsen CK, Bartlett SE, Janak PH and Ron D. Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor. Biol Psychiatry. 2009 Jul 15;66(2):146-53.
Logrip, M.L., Janak, P.H. andRon, D. Escalating ethanol intake is associated with altered corticostriatal BDNF expression.J Neurochem. 2009 Jun;109(5):1459-68.
Carnicella S, Ahmadiantehrani S, Janak PH and Ron D. GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcohol Clin Exp Res. 2009 Jun;33(6):1012-24.
Carnicella S and Ron D. GDNF--a potential target to treat addiction. Pharmacol Ther. 2009 Apr;122(1):9-18.
Carnicella S, AmamotoR, and Ron D. Excessive ethanol consumption is blocked by GDNF. Alcohol. 2009 Feb;43(1):35-43.
Rewal, M., Jurd, R., Gill, T.M., He, D.Y., Ron, D. and Janak, P.H. "Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol." J Neurosci. 2009 Jan 14; 29(2):543-9.
Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S. PKCbetaII modulates translation independently from mTOR and through RACK1. Biochem J. 2008 Oct 1;415(1):77-85.
Carnicella S, Kharazia V., Jeanblanc J., Janak PH and Ron D. GDNF – a fast acting potent inhibitor of motivation for alcohol seeking. PNAS. 2008 Jun 10;105(23):8114-9.
He D.-Y. and Ron D. Glial Cell Line-derived Neurotrophic Factor Reverses Ethanol-mediated Increases in Tyrosine Hydroxylase Immunoreactivity via Altering the Activity of Heat Shock Protein 90. J. Biol. Chem. 2008 May 9:283(19):12811-12818.
Logrip M, Janak PH andRon D. Dynorphin Is A Downstream Effector Of Striatal BDNF Regulation Of Ethanol. FASEB J. 2008 Jul;22(7):2393-404.
Jurd R, Thornton C, Wang J, Luong K, Phamluong K, Kharazia V, Gibb S.L., and Ron D. Mind bomb-2 is an E3 ligase that ubiquitinates the NMDA receptor NR2B subunit in a phosphorylation-dependent manner. J. Biol. Chem. 2008 Jan 4;283(1):301-10.
Newton PM and Ron D. Protein kinase C and alcohol addiction. Pharmacol Res. 2007 Jun;55(6):570-7.
Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi J, Chaudhri N, Janak PH, Lovinger DM and Ron D. Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior. J. Neurosci. 2007;27 3593-3602.
Schilstrom B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, Carman M, Singh V, Mailliard WS, Ron D., Bonci A. Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors. J Neurosci. 2006 Aug 15;26(33):8549-58.
He, D.-Y. and Ron, D. Autoregulation of Glial Cell Line Derived Neurotrophic Factor Expression: Implications for the Long-Lasting Actions of the Anti-Addiction Drug, Ibogaine. FASEB J. 2006 Nov;20(13):2420-2.
Jeanblanc J, He DY, McGough NN, Logrip ML, Phamluong K, Janak PH, Ron D. The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. J Neurosci. 2006 Feb 1;26(5):1457-64.
Suvarna N, Borgland S, Auberson YP, Bonci A, Ron D. Acute ethanol exposure alters functional NMDA receptor NR2 subunit ratio via H-Ras. J Biological Chemistry 280:31450-31459, 2005.
He D-Y, McGough NNH, Ravindranathan A, Jeanblanc J, Logrip ML, Phamluong K, Janak PH, Ron D. The glial derived neurotrophic factor mediates the desirable actions of the anti-addiction drug Ibogaine. J Neuroscience 25:619-628, 2005. UCSF Press Release.
McGough NN, He DY, Logrip ML, Jeanblanc J, Phamluong K, Luong K, Kharazia V, Janak PH, Ron D. RACK1 and brain-derived neurotrophic factor: A homeostatis pathway that regulates alcohol addiction. J Neuroscience 24:10542-10552, 2004.
Thornton C, Tang K-C, Phamluong K, Luong K, Vagts A, Nikanjam D, Yaka R, Ron D. Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization. J Biological Chemistry 279(30):31357-31364, 2004.
Yaka R, Tang K-C, Camarini R, Ron D. Fyn kinase and NR2B containing NMDA receptors regulate acute ethanol sensitivity but not intake or conditioned reward. Alcohol Clin Exp Res 27:1736-1742, 2003.
Vagts AJ, He D-Y, Ron D. Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1. Alcohol Clin Exp Res 27:1599-1605, 2003.
Ungless M, Singh V, Crowder TL, Yaka R, Ron D, Bonci A. Corticotropin-releasing factor (CRF) requires CRF-binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron 39:401-407, 2003.
Thornton C, Yaka R, Dinh S, Ron D. H-Ras modulates N-Methyl-D-Aspartate receptor function via inhibition of Src tyrosine kinase activity. J Biological Chemistry 278:23823-23829, 2003.
Yaka R, Phamluong K, Ron D. Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neuroscience 23:3623-3632, 2003.
Yaka R, Phamluong K, Vagts AJ, Ron D. Pituitary adenylate cyclase activating polypeptide (PACAP(1-38)) enhances NMDA receptor function and BDNF expression via RACK1. J Biological Chemistry 278:9630-9638, 2003.
He D-Y, Vagts AJ, Yaka R, Ron D. Ethanol induces gene expression via the nuclear compartmentalization of RACK1. Molecular Pharmacology 62(2):272-280, 2002.
Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D. NMDA-receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci USA 99:5710-5715, 2002.
Ron D, Vagts AJ, Dohrman DP, Yaka R, Jiang Z, Yao L, Crabbe J, Grisel JE, Diamond I. Uncoupling of bIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB J 14:2303-2314, 2000.
Ron, D., Jiang, Z., Yao, L., Vagts, A.J., Diamond, I., Gordon, A.S. Coordinated movement of RACK1 with activated bIIPKC.Journal of Biological Chemistry, 274: p. 27039-27046, 1999.
Ron, D., Napolitano, E. W., Voronova, A., Vasquez, N.J., Roberts, D.N., Calio, B.L., Caothien, R.H., Pettiford, S.M., Wellik, S., Mandac, J.B., Kauvar, L. Direct interaction in T-cells between PKC and the Tyrosine Kinase p59fyn. Journal of Biological Chemistry, 274: p. 19003-19010, 1999.
Ron, D. and Kazanietz, M.G. New insights of Protein Kinase C and novel Phorbol Ester Receptors. FASEB Journal, 13: p.1658-1676,1999.
Rodriguez, M., Ron, D., Kazushige, T., Chen, C.-H., Mochly-Rosen, D. RACK1, a Protein Kinase C anchoring protein coordinates the binding of activated Protein Kinase C and select pleckstrin homologydomains in vitro. Biochemistry, 38: p. 13787-13794, 1999.
Yedovitzky, M., Mochly-Rosen, D., Ron, D., Gray, M. O., Johnson, J. A., Abramovitch, E., Cerasi, E., and Nesher, R. Translocation inhibitors define specificity of protein kinase C isozymes in pancreatic beta cells. Journal of Biological Chemistry (Communication), 272: p. 1417-1420, 1997.
Ron, D., Luo, J., and Mochly-Rosen, D. C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo.Journal of Biological Chemistry, 270: p. 24180-7, 1995.
Ron, D., and Mochly-Rosen, D. A new autoregulatory region in protein kinase C - the pseudo-RACK binding site. Proceedings of the National Academy of Sciences, 92: p. 492-496, 1995.
Ron, D., and Mochly-Rosen, D. Agonists and antagonists of protein kinase C function, derived from its binding proteins. Journal of Biological Chemistry (Communication), 269: p. 21395-21398, 1994.
Ron, D., Chen, C. H., Caldwell, J., Jamieson, L., Orr E., and Mochly-Rosen, D. Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proceedings of the National Academy of Sciences, 91: p. 839-43, 1994.
Warnault V, Ron D. Chromatin remodeling: a new landscape to treat harmful alcohol-use disorders. Future Med Chem. 2013 Nov;5(17):2011-3.
Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, and Ron D. Protein Tyrosine Phosphatase {alpha} in the Dorsomedial Striatum Promotes Excessive Ethanol-Drinking Behaviors J. Neurosci. 2013;33 14369-14378
Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA. RACK(1) to the future - a historical perspective. Cell Commun Signal. 2013 Aug 1;11(1):53.
Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug;16(8):1094-100.
Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci. 2013 Aug;16(8):1111-7.
Jeanblanc J, Logrip ML, Janak PH, Ron D. BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. Eur J Neurosci. 2013 Feb;37(4):607-12.
Warnault V, Darcq E, Levine A, Barak S, Ron D. Chromatin remodeling - a novel strategy to control excessive alcohol drinking.Transl Psychiatry. 2013 Feb 19;3:e231.
Ahmadiantehrani S, Ron D. Dopamine D2 Receptor Activation Leads To An Upregulation Of Glial Cell Line-Derived Neurotrophic Factor Via Gβγ-Erk1/2-Dependent Induction Of Zif268. J Neurochem 2013 Apr;125(2):193-204.
Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res. 2013 Jan;37(1):8-15.
Ron D. and Messing RO. Signaling pathways mediating alcohol effects. In: Current Topics in Behavioral Neuroscience-Behavioral Neurobiology of Alcohol Addiction. Spanagel and Sommer (eds), Springer-Verlag, Heidelberg. Current Topics in Behavioral Neurosciences, 2013, Volume 13, 87-126.
Ben Hamida S., Neasta J., Lasek A.W., Kharazia V., Zou M., Carnicella S., Janak P.H., Ron D. The Small G Protein H-Ras in the Mesolimbic System Is a Molecular Gateway to Alcohol-Seeking and Excessive Drinking Behaviors. J. Neurosci. 2012;32 15849-15858. F1000 Prime Recommended, UCSF Press Release.
Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S, and Ron D. Ethanol-Mediated Facilitation of AMPA Receptor Function in the Dorsomedial Striatum: Implications for Alcohol Drinking Behavior. J. Neurosci. 2012;32 15124-15132.
Neasta J, Kiely PA, He D-Y, Adams DR, O'Connor R and Ron D. Direct interaction between scaffolding proteins RACK1 and 14-3-3{zeta} regulates brain-derived neurotrophic factor (BDNF) transcription. J. Biol. Chem. 2012; 287(1): p. 322-336.
Barak S, Ahmadiantehrani S, Kharazia V and Ron D. Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. Transl Psychiatry (2011) 1: e60.
Adams DR, Ron D, Kiely PA. RACK1, A Multifaceted Scaffolding Protein: Structure and Function. Cell Commun Signal. 2011 Oct 6;9(1):22.
Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ. Striatal Involvement in Human Alcoholism and Alcohol Consumption, and Withdrawal in Animal Models. Alcohol Clin Exp Res. 2011 Oct;35(10):1739-1748.
Gibb SL, Ben Hamida S, Lanfranco MF and Ron D. Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of PTPα. J Neurochem. 2011 Oct 11.
Barak S., Carnicella S., Yowell Q.V., Ron D. Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking. J.Neurosci. 2011 July 6;31 9885-9894
Neasta J, Ben Hamida S, Yowell QV, Carnicella S and Ron D. AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biological Psychiatry. Biol Psychiatry. 2011 Sep 15;70(6):575-82.
Wang J., Lanfranco M. F., Gibb S. L., Ron D. Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum. Channels (Austin). 2011 May-June;5(3);205-209.
Nie H., Rewal M., Gill T. M., Ron D. and Janak P. H. Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. PNAS 2011 Feb 22.
Gibb S. L., Jeanblanc J., Barak S., Yowell Q. V., Yaka R. and Ron D. Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward. J. Neurosci. 2011, Feb 9; 31(6):2180–2187.
Carnicella S., Yowell Q. and Ron D. Regulation of Operant Oral Ethanol Self-Administration: A Dose–Response Curve Study in Rats. Alcoholism: Clinical and Experimental Research. 35(1): 2011.
Neasta J., Hamida S., Yowell Q., Carnicella S. and Ron D. Role for Mammalian Target of Rapamycin Complex 1 Signaling in Neuroadaptations Underlying Alcohol-Related Disorders. Proceedings of the National Academy of Sciences. 107(46): p. 20093–20098, 2010. Supporting Information.
Wang J., Carnicella S., He D.Y., Ahmadiantehrani S., Barak S., Ben Hamida S., Kharazia V., Zapata A, Shippenberg T.S. and Ron D. Nucleus Accumbens-Derived GDNF Is a Retrograde Enhancer of Dopaminergic Tone in the Mesocorticolimbic System. J. Neurosci. 2010, Oct 27; 30 14502-14512.
Wang J., Lanfranco M.F., Gibb S.L., Yowell Q.V., Carnicella S., Ron D. Long-Lasting Adaptations of the NR2B-containing NMDA Receptors in the Dorsomedial Striatum Play a Crucial Role in Alcohol Consumption and Relapse. J. Neurosci. 2010, July 28; 30 10187-10198.
Carnicella S., He D-Y, Yowell Q.V., Glick S.D. and Ron D. Noribogaine, but not 18-MC, Exhibits Similar Actions as Ibogaine on GDNF Expression and Ethanol Self-Administration. Addiction Biology, 2010, Oct 6; 15(4), 424-433.
He, D-Y, Neasta, J and Ron, D. Epigenetic regulation of BDNF expression via the scaffolding protein RACK1. J Biol Chem. 2010 Jun 18;285(25):19043-50.
Jeanblanc J, He D-Y, Carnicella S, Kharazia V, Janak PH, Ron D. Endogenous BDNF in the Dorsolateral Striatum Gates Alcohol Drinking. J. Neurosci. 2009, Oct 28;29(43):13494-3502.
Logrip, M.L., Janak, P.H., and Ron, D. Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H. Alcohol. 2009 Aug;43(5):359-365.
Carnicella S, Ahmadiantehrani S, He DY, Nielsen CK, Bartlett SE, Janak PH and Ron D. Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor. Biol Psychiatry. 2009 Jul 15;66(2):146-53.
Logrip, M.L., Janak, P.H. andRon, D. Escalating ethanol intake is associated with altered corticostriatal BDNF expression.J Neurochem. 2009 Jun;109(5):1459-68.
Carnicella S, Ahmadiantehrani S, Janak PH and Ron D. GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcohol Clin Exp Res. 2009 Jun;33(6):1012-24.
Carnicella S and Ron D. GDNF--a potential target to treat addiction. Pharmacol Ther. 2009 Apr;122(1):9-18.
Carnicella S, AmamotoR, and Ron D. Excessive ethanol consumption is blocked by GDNF. Alcohol. 2009 Feb;43(1):35-43.
Rewal, M., Jurd, R., Gill, T.M., He, D.Y., Ron, D. and Janak, P.H. "Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol." J Neurosci. 2009 Jan 14; 29(2):543-9.
Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S. PKCbetaII modulates translation independently from mTOR and through RACK1. Biochem J. 2008 Oct 1;415(1):77-85.
Carnicella S, Kharazia V., Jeanblanc J., Janak PH and Ron D. GDNF – a fast acting potent inhibitor of motivation for alcohol seeking. PNAS. 2008 Jun 10;105(23):8114-9.
He D.-Y. and Ron D. Glial Cell Line-derived Neurotrophic Factor Reverses Ethanol-mediated Increases in Tyrosine Hydroxylase Immunoreactivity via Altering the Activity of Heat Shock Protein 90. J. Biol. Chem. 2008 May 9:283(19):12811-12818.
Logrip M, Janak PH andRon D. Dynorphin Is A Downstream Effector Of Striatal BDNF Regulation Of Ethanol. FASEB J. 2008 Jul;22(7):2393-404.
Jurd R, Thornton C, Wang J, Luong K, Phamluong K, Kharazia V, Gibb S.L., and Ron D. Mind bomb-2 is an E3 ligase that ubiquitinates the NMDA receptor NR2B subunit in a phosphorylation-dependent manner. J. Biol. Chem. 2008 Jan 4;283(1):301-10.
Newton PM and Ron D. Protein kinase C and alcohol addiction. Pharmacol Res. 2007 Jun;55(6):570-7.
Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi J, Chaudhri N, Janak PH, Lovinger DM and Ron D. Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior. J. Neurosci. 2007;27 3593-3602.
Schilstrom B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, Carman M, Singh V, Mailliard WS, Ron D., Bonci A. Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors. J Neurosci. 2006 Aug 15;26(33):8549-58.
He, D.-Y. and Ron, D. Autoregulation of Glial Cell Line Derived Neurotrophic Factor Expression: Implications for the Long-Lasting Actions of the Anti-Addiction Drug, Ibogaine. FASEB J. 2006 Nov;20(13):2420-2.
Jeanblanc J, He DY, McGough NN, Logrip ML, Phamluong K, Janak PH, Ron D. The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. J Neurosci. 2006 Feb 1;26(5):1457-64.
Suvarna N, Borgland S, Auberson YP, Bonci A, Ron D. Acute ethanol exposure alters functional NMDA receptor NR2 subunit ratio via H-Ras. J Biological Chemistry 280:31450-31459, 2005.
He D-Y, McGough NNH, Ravindranathan A, Jeanblanc J, Logrip ML, Phamluong K, Janak PH, Ron D. The glial derived neurotrophic factor mediates the desirable actions of the anti-addiction drug Ibogaine. J Neuroscience 25:619-628, 2005. UCSF Press Release.
McGough NN, He DY, Logrip ML, Jeanblanc J, Phamluong K, Luong K, Kharazia V, Janak PH, Ron D. RACK1 and brain-derived neurotrophic factor: A homeostatis pathway that regulates alcohol addiction. J Neuroscience 24:10542-10552, 2004.
Thornton C, Tang K-C, Phamluong K, Luong K, Vagts A, Nikanjam D, Yaka R, Ron D. Spatial and temporal regulation of RACK1 function and N-methyl-D-aspartate receptor activity through WD40 motif-mediated dimerization. J Biological Chemistry 279(30):31357-31364, 2004.
Yaka R, Tang K-C, Camarini R, Ron D. Fyn kinase and NR2B containing NMDA receptors regulate acute ethanol sensitivity but not intake or conditioned reward. Alcohol Clin Exp Res 27:1736-1742, 2003.
Vagts AJ, He D-Y, Ron D. Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1. Alcohol Clin Exp Res 27:1599-1605, 2003.
Ungless M, Singh V, Crowder TL, Yaka R, Ron D, Bonci A. Corticotropin-releasing factor (CRF) requires CRF-binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron 39:401-407, 2003.
Thornton C, Yaka R, Dinh S, Ron D. H-Ras modulates N-Methyl-D-Aspartate receptor function via inhibition of Src tyrosine kinase activity. J Biological Chemistry 278:23823-23829, 2003.
Yaka R, Phamluong K, Ron D. Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol. J Neuroscience 23:3623-3632, 2003.
Yaka R, Phamluong K, Vagts AJ, Ron D. Pituitary adenylate cyclase activating polypeptide (PACAP(1-38)) enhances NMDA receptor function and BDNF expression via RACK1. J Biological Chemistry 278:9630-9638, 2003.
He D-Y, Vagts AJ, Yaka R, Ron D. Ethanol induces gene expression via the nuclear compartmentalization of RACK1. Molecular Pharmacology 62(2):272-280, 2002.
Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D. NMDA-receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci USA 99:5710-5715, 2002.
Ron D, Vagts AJ, Dohrman DP, Yaka R, Jiang Z, Yao L, Crabbe J, Grisel JE, Diamond I. Uncoupling of bIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB J 14:2303-2314, 2000.
Ron, D., Jiang, Z., Yao, L., Vagts, A.J., Diamond, I., Gordon, A.S. Coordinated movement of RACK1 with activated bIIPKC.Journal of Biological Chemistry, 274: p. 27039-27046, 1999.
Ron, D., Napolitano, E. W., Voronova, A., Vasquez, N.J., Roberts, D.N., Calio, B.L., Caothien, R.H., Pettiford, S.M., Wellik, S., Mandac, J.B., Kauvar, L. Direct interaction in T-cells between PKC and the Tyrosine Kinase p59fyn. Journal of Biological Chemistry, 274: p. 19003-19010, 1999.
Ron, D. and Kazanietz, M.G. New insights of Protein Kinase C and novel Phorbol Ester Receptors. FASEB Journal, 13: p.1658-1676,1999.
Rodriguez, M., Ron, D., Kazushige, T., Chen, C.-H., Mochly-Rosen, D. RACK1, a Protein Kinase C anchoring protein coordinates the binding of activated Protein Kinase C and select pleckstrin homologydomains in vitro. Biochemistry, 38: p. 13787-13794, 1999.
Yedovitzky, M., Mochly-Rosen, D., Ron, D., Gray, M. O., Johnson, J. A., Abramovitch, E., Cerasi, E., and Nesher, R. Translocation inhibitors define specificity of protein kinase C isozymes in pancreatic beta cells. Journal of Biological Chemistry (Communication), 272: p. 1417-1420, 1997.
Ron, D., Luo, J., and Mochly-Rosen, D. C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo.Journal of Biological Chemistry, 270: p. 24180-7, 1995.
Ron, D., and Mochly-Rosen, D. A new autoregulatory region in protein kinase C - the pseudo-RACK binding site. Proceedings of the National Academy of Sciences, 92: p. 492-496, 1995.
Ron, D., and Mochly-Rosen, D. Agonists and antagonists of protein kinase C function, derived from its binding proteins. Journal of Biological Chemistry (Communication), 269: p. 21395-21398, 1994.
Ron, D., Chen, C. H., Caldwell, J., Jamieson, L., Orr E., and Mochly-Rosen, D. Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proceedings of the National Academy of Sciences, 91: p. 839-43, 1994.