Publications
Liu F., Laguesse S., Legastelois R., Morisot N., Ben Hamida S. and Ron D. mTORC1-dependent Translation of Collapsin Response Mediator Protein-2 Drives Neuroadaptations Underlying Excessive Alcohol Drinking Behaviors. Mol Psychiatry. 2017 Jan;22(1):89-101.
F100Prime Recommended
Morisot N, Ron D. Alcohol-Dependent Molecular Adaptations of the NMDA Receptor System. Genes Brain Behav. 2017 Jan;16(1):139-148. doi: 10.1111/gbb.12363.
Laguesse S, Morisot N, Phamluong K, Ron D. Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents. Addict Biol. 2016 Oct 20. doi: 10.1111/adb.12464. [Epub ahead of print]
Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, and Ron D. The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. J. Neurosci. 2016, 36(39):10116-10127.
Neasta J, Fiorenza A, He D-Y, Phamluong K, Kiely PA, Ron D. Activation of the cAMP Pathway Induces RACK1-Dependent Binding of β-Actin to BDNF Promoter. PLoS One. 2016 Aug 9;11(18):e0160948.
Beckley J.T., Laguesse S., Phamluong K., Morisot N., Wegner S.A., and Ron D. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity In Nucleus Accumbens Dopamine D1 Receptor Neurons. J. Neurosci. 2016, 36(3): 701-713.
Ron D. and Barak S. Molecular mechanisms underlying alcohol-drinking behaviors. Nature Reviews Neuroscience. 17, 576–591, 2016.
Beckley JT and Ron D. Molecules to Medicine with mTOR. Elsevier Academic Press. 2016. 215-226.
Wang J, Cheng Y, Wang X, Hellard ER, Ma T, Gil H, Ben Hamida S, and Ron D. Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum. J. Neurosci. 2015; 35(33): 11634-11643.
This Week in The Journal
Editor’s Choice Sci Transl. Med.
Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. The Bdnf Val68 to Met Polymorphism Increases Compulsive Alcohol Drinking In Mice Which Is Reversed By TrkB Activation. Biol Psychiatry. 2016 Mar 15;79(6):463-73.
F100Prime Recommended
Biol Psychiatry. 2016 Mar 15;79(6):427-9.
Darcq E, Warnault V, Phamluong K, Besserer GM, Liu F, Ron D. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Mol Psychiatry. 2015 Oct;20(10):1261.
Barak S, Wang J, Ahmadiantehrani S, Ben Hamida S, Kells AP, Forsayeth J, Bankiewicz KS, Ron D. Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse. Addict Biol. 2015 Jul;20(4):629-4.
Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D. Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking. PLoS One. 2015 May 20;10(5):e0127408.
Logrip ML, Barak S, Warnault V, Ron D. Corticostriatal BDNF and alcohol addiction. Brain Res. 2015 Mar 21. pii: S0006-8993(15)00221-8.
Neasta J, Barak S, Ben Hamida S, Ron D. mTOR Complex 1: A Key Player in Neuroadaptations Induced by Drugs of Abuse. J Neurochem. 2014 Jul;130(2):172-84.
Ahmadiantehrani S, Barak S, Ron D.GDNF is a novel ethanol-responsive gene in the VTA: implications for the development and persistence of excessive drinking. Addict Biol. 2014 Jul;19(4):623-33.
Darcq E, Ben Hamida S, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D. Inhibition of Striatal-enriched Tyrosine Phosphatase 61 in the Dorsomedial Striatum is Sufficient to Increase Ethanol Consumption. J Neurochem. 2014 Jun;129(6):1024-34.
Carnicella S, Ron D, Barak S. Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol. 2014 May;48(3):243-52.
Warnault V, Ron D. Chromatin remodeling: a new landscape to treat harmful alcohol-use disorders. Future Med Chem. 2013 Nov;5(17):2011-3.
Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, and Ron D. Protein Tyrosine Phosphatase {alpha} in the Dorsomedial Striatum Promotes Excessive Ethanol-Drinking Behaviors J. Neurosci. 2013;33 14369-14378
Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA. RACK(1) to the future - a historical perspective. Cell Commun Signal. 2013 Aug 1;11(1):53.
Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug;16(8):1094-100.
Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci. 2013 Aug;16(8):1111-7.
Jeanblanc J, Logrip ML, Janak PH, Ron D. BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. Eur J Neurosci. 2013 Feb;37(4):607-12.
Warnault V, Darcq E, Levine A, Barak S, Ron D. Chromatin remodeling - a novel strategy to control excessive alcohol drinking.Transl Psychiatry. 2013 Feb 19;3:e231.
Ahmadiantehrani S, Ron D. Dopamine D2 Receptor Activation Leads To An Upregulation Of Glial Cell Line-Derived Neurotrophic Factor Via Gβγ-Erk1/2-Dependent Induction Of Zif268. J Neurochem 2013 Apr;125(2):193-204.
Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res. 2013 Jan;37(1):8-15.
Ron D. and Messing RO. Signaling pathways mediating alcohol effects. In: Current Topics in Behavioral Neuroscience-Behavioral Neurobiology of Alcohol Addiction. Spanagel and Sommer (eds), Springer-Verlag, Heidelberg. Current Topics in Behavioral Neurosciences, 2013, Volume 13, 87-126.
Ben Hamida S., Neasta J., Lasek A.W., Kharazia V., Zou M., Carnicella S., Janak P.H., Ron D. The Small G Protein H-Ras in the Mesolimbic System Is a Molecular Gateway to Alcohol-Seeking and Excessive Drinking Behaviors. J. Neurosci. 2012;32 15849-15858.
Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S, and Ron D. Ethanol-Mediated Facilitation of AMPA Receptor Function in the Dorsomedial Striatum: Implications for Alcohol Drinking Behavior. J. Neurosci. 2012;32 15124-15132.
Neasta J, Kiely PA, He D-Y, Adams DR, O'Connor R and Ron D. Direct interaction between scaffolding proteins RACK1 and 14-3-3{zeta} regulates brain-derived neurotrophic factor (BDNF) transcription. J. Biol. Chem. 2012; 287(1): p. 322-336.
Barak S, Ahmadiantehrani S, Kharazia V and Ron D. Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. Transl Psychiatry (2011) 1: e60.
Adams DR, Ron D, Kiely PA. RACK1, A Multifaceted Scaffolding Protein: Structure and Function. Cell Commun Signal. 2011 Oct 6;9(1):22.
Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ. Striatal Involvement in Human Alcoholism and Alcohol Consumption, and Withdrawal in Animal Models. Alcohol Clin Exp Res. 2011 Oct;35(10):1739-1748.
Gibb SL, Ben Hamida S, Lanfranco MF and Ron D. Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of PTPα. J Neurochem. 2011 Oct 11.
Barak S., Carnicella S., Yowell Q.V., Ron D. Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking. J.Neurosci. 2011 July 6;31 9885-9894
Neasta J, Ben Hamida S, Yowell QV, Carnicella S and Ron D. AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biological Psychiatry. Biol Psychiatry. 2011 Sep 15;70(6):575-82.
Wang J., Lanfranco M. F., Gibb S. L., Ron D. Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum. Channels (Austin). 2011 May-June;5(3);205-209.
Nie H., Rewal M., Gill T. M., Ron D. and Janak P. H. Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. PNAS 2011 Feb 22.
Gibb S. L., Jeanblanc J., Barak S., Yowell Q. V., Yaka R. and Ron D. Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward. J. Neurosci. 2011, Feb 9; 31(6):2180–2187.
Carnicella S., Yowell Q. and Ron D. Regulation of Operant Oral Ethanol Self-Administration: A Dose–Response Curve Study in Rats. Alcoholism: Clinical and Experimental Research. 35(1): 2011.
Neasta J., Hamida S., Yowell Q., Carnicella S. and Ron D. Role for Mammalian Target of Rapamycin Complex 1 Signaling in Neuroadaptations Underlying Alcohol-Related Disorders. Proceedings of the National Academy of Sciences. 107(46): p. 20093–20098, 2010. Supporting Information.
Wang J., Carnicella S., He D.Y., Ahmadiantehrani S., Barak S., Ben Hamida S., Kharazia V., Zapata A, Shippenberg T.S. and Ron D. Nucleus Accumbens-Derived GDNF Is a Retrograde Enhancer of Dopaminergic Tone in the Mesocorticolimbic System. J. Neurosci. 2010, Oct 27; 30 14502-14512.
Wang J., Lanfranco M.F., Gibb S.L., Yowell Q.V., Carnicella S., Ron D. Long-Lasting Adaptations of the NR2B-containing NMDA Receptors in the Dorsomedial Striatum Play a Crucial Role in Alcohol Consumption and Relapse. J. Neurosci. 2010, July 28; 30 10187-10198.
Carnicella S., He D-Y, Yowell Q.V., Glick S.D. and Ron D. Noribogaine, but not 18-MC, Exhibits Similar Actions as Ibogaine on GDNF Expression and Ethanol Self-Administration. Addiction Biology, 2010, Oct 6; 15(4), 424-433.
He, D-Y, Neasta, J and Ron, D. Epigenetic regulation of BDNF expression via the scaffolding protein RACK1. J Biol Chem. 2010 Jun 18;285(25):19043-50.
Jeanblanc J, He D-Y, Carnicella S, Kharazia V, Janak PH, Ron D. Endogenous BDNF in the Dorsolateral Striatum Gates Alcohol Drinking. J. Neurosci. 2009, Oct 28;29(43):13494-3502.
Logrip, M.L., Janak, P.H., and Ron, D. Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H. Alcohol. 2009 Aug;43(5):359-365.
Carnicella S, Ahmadiantehrani S, He DY, Nielsen CK, Bartlett SE, Janak PH and Ron D. Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor. Biol Psychiatry. 2009 Jul 15;66(2):146-53.
Logrip, M.L., Janak, P.H. andRon, D. Escalating ethanol intake is associated with altered corticostriatal BDNF expression.J Neurochem. 2009 Jun;109(5):1459-68.
Carnicella S, Ahmadiantehrani S, Janak PH and Ron D. GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcohol Clin Exp Res. 2009 Jun;33(6):1012-24.
Carnicella S and Ron D. GDNF--a potential target to treat addiction. Pharmacol Ther. 2009 Apr;122(1):9-18.
Carnicella S, AmamotoR, and Ron D. Excessive ethanol consumption is blocked by GDNF. Alcohol. 2009 Feb;43(1):35-43.
Rewal, M., Jurd, R., Gill, T.M., He, D.Y., Ron, D. and Janak, P.H. "Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol." J Neurosci. 2009 Jan 14; 29(2):543-9.
Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S. PKCbetaII modulates translation independently from mTOR and through RACK1. Biochem J. 2008 Oct 1;415(1):77-85.
Carnicella S, Kharazia V., Jeanblanc J., Janak PH and Ron D. GDNF – a fast acting potent inhibitor of motivation for alcohol seeking. PNAS. 2008 Jun 10;105(23):8114-9.
He D.-Y. and Ron D. Glial Cell Line-derived Neurotrophic Factor Reverses Ethanol-mediated Increases in Tyrosine Hydroxylase Immunoreactivity via Altering the Activity of Heat Shock Protein 90. J. Biol. Chem. 2008 May 9:283(19):12811-12818.
Logrip M, Janak PH andRon D. Dynorphin Is A Downstream Effector Of Striatal BDNF Regulation Of Ethanol. FASEB J. 2008 Jul;22(7):2393-404.
Jurd R, Thornton C, Wang J, Luong K, Phamluong K, Kharazia V, Gibb S.L., and Ron D. Mind bomb-2 is an E3 ligase that ubiquitinates the NMDA receptor NR2B subunit in a phosphorylation-dependent manner. J. Biol. Chem. 2008 Jan 4;283(1):301-10.
Newton PM and Ron D. Protein kinase C and alcohol addiction. Pharmacol Res. 2007 Jun;55(6):570-7.
Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi J, Chaudhri N, Janak PH, Lovinger DM and Ron D. Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior. J. Neurosci. 2007;27 3593-3602.
Schilstrom B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, Carman M, Singh V, Mailliard WS, Ron D., Bonci A. Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors. J Neurosci. 2006 Aug 15;26(33):8549-58.
He, D.-Y. and Ron, D. Autoregulation of Glial Cell Line Derived Neurotrophic Factor Expression: Implications for the Long-Lasting Actions of the Anti-Addiction Drug, Ibogaine. FASEB J. 2006 Nov;20(13):2420-2.
Ron, D. and Janak, P.H. GDNF and Addiction. 2frevneuro.2005.16.4href="dg/viewarticle/j-002frevneuro.2005.16.4-002frevneuro.2005.16.4.277-002frevneuro.2005.16.4.277.xm">2frevneuro.2005.16.4.277href="dg/viewarticle/j-002frevneuro.2005.16.4-002frevneuro.2005.16.4.277-002frevneuro.2005.16.4.277.xm">2frevneuro.2005.16.4.277.xml;jsessionid=26D3A63C6F302F791CC10FDF1AD6E9E3">Reviews in the Neurosciences. 2005; 16:277-285.
Ron, D. and Jurd, R. The "ups and downs" of signaling cascades in addiction. Science STKE. 2005; 309:14,5.
Ron, D. Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol. Neuroscientist. 2004; 10:325-336.
F100Prime Recommended
Morisot N, Ron D. Alcohol-Dependent Molecular Adaptations of the NMDA Receptor System. Genes Brain Behav. 2017 Jan;16(1):139-148. doi: 10.1111/gbb.12363.
Laguesse S, Morisot N, Phamluong K, Ron D. Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents. Addict Biol. 2016 Oct 20. doi: 10.1111/adb.12464. [Epub ahead of print]
Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, and Ron D. The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. J. Neurosci. 2016, 36(39):10116-10127.
Neasta J, Fiorenza A, He D-Y, Phamluong K, Kiely PA, Ron D. Activation of the cAMP Pathway Induces RACK1-Dependent Binding of β-Actin to BDNF Promoter. PLoS One. 2016 Aug 9;11(18):e0160948.
Beckley J.T., Laguesse S., Phamluong K., Morisot N., Wegner S.A., and Ron D. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity In Nucleus Accumbens Dopamine D1 Receptor Neurons. J. Neurosci. 2016, 36(3): 701-713.
Ron D. and Barak S. Molecular mechanisms underlying alcohol-drinking behaviors. Nature Reviews Neuroscience. 17, 576–591, 2016.
Beckley JT and Ron D. Molecules to Medicine with mTOR. Elsevier Academic Press. 2016. 215-226.
Wang J, Cheng Y, Wang X, Hellard ER, Ma T, Gil H, Ben Hamida S, and Ron D. Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum. J. Neurosci. 2015; 35(33): 11634-11643.
This Week in The Journal
Editor’s Choice Sci Transl. Med.
Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. The Bdnf Val68 to Met Polymorphism Increases Compulsive Alcohol Drinking In Mice Which Is Reversed By TrkB Activation. Biol Psychiatry. 2016 Mar 15;79(6):463-73.
F100Prime Recommended
Biol Psychiatry. 2016 Mar 15;79(6):427-9.
Darcq E, Warnault V, Phamluong K, Besserer GM, Liu F, Ron D. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Mol Psychiatry. 2015 Oct;20(10):1261.
Barak S, Wang J, Ahmadiantehrani S, Ben Hamida S, Kells AP, Forsayeth J, Bankiewicz KS, Ron D. Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse. Addict Biol. 2015 Jul;20(4):629-4.
Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D. Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking. PLoS One. 2015 May 20;10(5):e0127408.
Logrip ML, Barak S, Warnault V, Ron D. Corticostriatal BDNF and alcohol addiction. Brain Res. 2015 Mar 21. pii: S0006-8993(15)00221-8.
Neasta J, Barak S, Ben Hamida S, Ron D. mTOR Complex 1: A Key Player in Neuroadaptations Induced by Drugs of Abuse. J Neurochem. 2014 Jul;130(2):172-84.
Ahmadiantehrani S, Barak S, Ron D.GDNF is a novel ethanol-responsive gene in the VTA: implications for the development and persistence of excessive drinking. Addict Biol. 2014 Jul;19(4):623-33.
Darcq E, Ben Hamida S, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D. Inhibition of Striatal-enriched Tyrosine Phosphatase 61 in the Dorsomedial Striatum is Sufficient to Increase Ethanol Consumption. J Neurochem. 2014 Jun;129(6):1024-34.
Carnicella S, Ron D, Barak S. Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol. 2014 May;48(3):243-52.
Warnault V, Ron D. Chromatin remodeling: a new landscape to treat harmful alcohol-use disorders. Future Med Chem. 2013 Nov;5(17):2011-3.
Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, and Ron D. Protein Tyrosine Phosphatase {alpha} in the Dorsomedial Striatum Promotes Excessive Ethanol-Drinking Behaviors J. Neurosci. 2013;33 14369-14378
Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA. RACK(1) to the future - a historical perspective. Cell Commun Signal. 2013 Aug 1;11(1):53.
Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug;16(8):1094-100.
Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci. 2013 Aug;16(8):1111-7.
Jeanblanc J, Logrip ML, Janak PH, Ron D. BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. Eur J Neurosci. 2013 Feb;37(4):607-12.
Warnault V, Darcq E, Levine A, Barak S, Ron D. Chromatin remodeling - a novel strategy to control excessive alcohol drinking.Transl Psychiatry. 2013 Feb 19;3:e231.
Ahmadiantehrani S, Ron D. Dopamine D2 Receptor Activation Leads To An Upregulation Of Glial Cell Line-Derived Neurotrophic Factor Via Gβγ-Erk1/2-Dependent Induction Of Zif268. J Neurochem 2013 Apr;125(2):193-204.
Davies DL, Bortolato M, Finn DA, Ramaker MJ, Barak S, Ron D, Liang J, Olsen RW. Recent advances in the discovery and preclinical testing of novel compounds for the prevention and/or treatment of alcohol use disorders. Alcohol Clin Exp Res. 2013 Jan;37(1):8-15.
Ron D. and Messing RO. Signaling pathways mediating alcohol effects. In: Current Topics in Behavioral Neuroscience-Behavioral Neurobiology of Alcohol Addiction. Spanagel and Sommer (eds), Springer-Verlag, Heidelberg. Current Topics in Behavioral Neurosciences, 2013, Volume 13, 87-126.
Ben Hamida S., Neasta J., Lasek A.W., Kharazia V., Zou M., Carnicella S., Janak P.H., Ron D. The Small G Protein H-Ras in the Mesolimbic System Is a Molecular Gateway to Alcohol-Seeking and Excessive Drinking Behaviors. J. Neurosci. 2012;32 15849-15858.
Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S, and Ron D. Ethanol-Mediated Facilitation of AMPA Receptor Function in the Dorsomedial Striatum: Implications for Alcohol Drinking Behavior. J. Neurosci. 2012;32 15124-15132.
Neasta J, Kiely PA, He D-Y, Adams DR, O'Connor R and Ron D. Direct interaction between scaffolding proteins RACK1 and 14-3-3{zeta} regulates brain-derived neurotrophic factor (BDNF) transcription. J. Biol. Chem. 2012; 287(1): p. 322-336.
Barak S, Ahmadiantehrani S, Kharazia V and Ron D. Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. Transl Psychiatry (2011) 1: e60.
Adams DR, Ron D, Kiely PA. RACK1, A Multifaceted Scaffolding Protein: Structure and Function. Cell Commun Signal. 2011 Oct 6;9(1):22.
Chen G, Cuzon Carlson VC, Wang J, Beck A, Heinz A, Ron D, Lovinger DM, Buck KJ. Striatal Involvement in Human Alcoholism and Alcohol Consumption, and Withdrawal in Animal Models. Alcohol Clin Exp Res. 2011 Oct;35(10):1739-1748.
Gibb SL, Ben Hamida S, Lanfranco MF and Ron D. Ethanol-induced increase in Fyn kinase activity in the dorsomedial striatum is associated with subcellular redistribution of PTPα. J Neurochem. 2011 Oct 11.
Barak S., Carnicella S., Yowell Q.V., Ron D. Glial cell line-derived neurotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking. J.Neurosci. 2011 July 6;31 9885-9894
Neasta J, Ben Hamida S, Yowell QV, Carnicella S and Ron D. AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biological Psychiatry. Biol Psychiatry. 2011 Sep 15;70(6):575-82.
Wang J., Lanfranco M. F., Gibb S. L., Ron D. Ethanol-mediated long-lasting adaptations of the NR2B-containing NMDA receptors in the dorsomedial striatum. Channels (Austin). 2011 May-June;5(3);205-209.
Nie H., Rewal M., Gill T. M., Ron D. and Janak P. H. Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. PNAS 2011 Feb 22.
Gibb S. L., Jeanblanc J., Barak S., Yowell Q. V., Yaka R. and Ron D. Lyn kinase regulates mesolimbic dopamine release: implication for alcohol reward. J. Neurosci. 2011, Feb 9; 31(6):2180–2187.
Carnicella S., Yowell Q. and Ron D. Regulation of Operant Oral Ethanol Self-Administration: A Dose–Response Curve Study in Rats. Alcoholism: Clinical and Experimental Research. 35(1): 2011.
Neasta J., Hamida S., Yowell Q., Carnicella S. and Ron D. Role for Mammalian Target of Rapamycin Complex 1 Signaling in Neuroadaptations Underlying Alcohol-Related Disorders. Proceedings of the National Academy of Sciences. 107(46): p. 20093–20098, 2010. Supporting Information.
Wang J., Carnicella S., He D.Y., Ahmadiantehrani S., Barak S., Ben Hamida S., Kharazia V., Zapata A, Shippenberg T.S. and Ron D. Nucleus Accumbens-Derived GDNF Is a Retrograde Enhancer of Dopaminergic Tone in the Mesocorticolimbic System. J. Neurosci. 2010, Oct 27; 30 14502-14512.
Wang J., Lanfranco M.F., Gibb S.L., Yowell Q.V., Carnicella S., Ron D. Long-Lasting Adaptations of the NR2B-containing NMDA Receptors in the Dorsomedial Striatum Play a Crucial Role in Alcohol Consumption and Relapse. J. Neurosci. 2010, July 28; 30 10187-10198.
Carnicella S., He D-Y, Yowell Q.V., Glick S.D. and Ron D. Noribogaine, but not 18-MC, Exhibits Similar Actions as Ibogaine on GDNF Expression and Ethanol Self-Administration. Addiction Biology, 2010, Oct 6; 15(4), 424-433.
He, D-Y, Neasta, J and Ron, D. Epigenetic regulation of BDNF expression via the scaffolding protein RACK1. J Biol Chem. 2010 Jun 18;285(25):19043-50.
Jeanblanc J, He D-Y, Carnicella S, Kharazia V, Janak PH, Ron D. Endogenous BDNF in the Dorsolateral Striatum Gates Alcohol Drinking. J. Neurosci. 2009, Oct 28;29(43):13494-3502.
Logrip, M.L., Janak, P.H., and Ron, D. Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H. Alcohol. 2009 Aug;43(5):359-365.
Carnicella S, Ahmadiantehrani S, He DY, Nielsen CK, Bartlett SE, Janak PH and Ron D. Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor. Biol Psychiatry. 2009 Jul 15;66(2):146-53.
Logrip, M.L., Janak, P.H. andRon, D. Escalating ethanol intake is associated with altered corticostriatal BDNF expression.J Neurochem. 2009 Jun;109(5):1459-68.
Carnicella S, Ahmadiantehrani S, Janak PH and Ron D. GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcohol Clin Exp Res. 2009 Jun;33(6):1012-24.
Carnicella S and Ron D. GDNF--a potential target to treat addiction. Pharmacol Ther. 2009 Apr;122(1):9-18.
Carnicella S, AmamotoR, and Ron D. Excessive ethanol consumption is blocked by GDNF. Alcohol. 2009 Feb;43(1):35-43.
Rewal, M., Jurd, R., Gill, T.M., He, D.Y., Ron, D. and Janak, P.H. "Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol." J Neurosci. 2009 Jan 14; 29(2):543-9.
Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S. PKCbetaII modulates translation independently from mTOR and through RACK1. Biochem J. 2008 Oct 1;415(1):77-85.
Carnicella S, Kharazia V., Jeanblanc J., Janak PH and Ron D. GDNF – a fast acting potent inhibitor of motivation for alcohol seeking. PNAS. 2008 Jun 10;105(23):8114-9.
He D.-Y. and Ron D. Glial Cell Line-derived Neurotrophic Factor Reverses Ethanol-mediated Increases in Tyrosine Hydroxylase Immunoreactivity via Altering the Activity of Heat Shock Protein 90. J. Biol. Chem. 2008 May 9:283(19):12811-12818.
Logrip M, Janak PH andRon D. Dynorphin Is A Downstream Effector Of Striatal BDNF Regulation Of Ethanol. FASEB J. 2008 Jul;22(7):2393-404.
Jurd R, Thornton C, Wang J, Luong K, Phamluong K, Kharazia V, Gibb S.L., and Ron D. Mind bomb-2 is an E3 ligase that ubiquitinates the NMDA receptor NR2B subunit in a phosphorylation-dependent manner. J. Biol. Chem. 2008 Jan 4;283(1):301-10.
Newton PM and Ron D. Protein kinase C and alcohol addiction. Pharmacol Res. 2007 Jun;55(6):570-7.
Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi J, Chaudhri N, Janak PH, Lovinger DM and Ron D. Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior. J. Neurosci. 2007;27 3593-3602.
Schilstrom B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, Carman M, Singh V, Mailliard WS, Ron D., Bonci A. Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors. J Neurosci. 2006 Aug 15;26(33):8549-58.
He, D.-Y. and Ron, D. Autoregulation of Glial Cell Line Derived Neurotrophic Factor Expression: Implications for the Long-Lasting Actions of the Anti-Addiction Drug, Ibogaine. FASEB J. 2006 Nov;20(13):2420-2.
Ron, D. and Janak, P.H. GDNF and Addiction. 2frevneuro.2005.16.4href="dg/viewarticle/j-002frevneuro.2005.16.4-002frevneuro.2005.16.4.277-002frevneuro.2005.16.4.277.xm">2frevneuro.2005.16.4.277href="dg/viewarticle/j-002frevneuro.2005.16.4-002frevneuro.2005.16.4.277-002frevneuro.2005.16.4.277.xm">2frevneuro.2005.16.4.277.xml;jsessionid=26D3A63C6F302F791CC10FDF1AD6E9E3">Reviews in the Neurosciences. 2005; 16:277-285.
Ron, D. and Jurd, R. The "ups and downs" of signaling cascades in addiction. Science STKE. 2005; 309:14,5.
Ron, D. Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol. Neuroscientist. 2004; 10:325-336.