Dorit Ron's Group
G protein-coupled receptor D1
Receptor Tyrosine Kinase: TrkB (BDNF) Ret (GDNF)
Channel: NMDA receptor
Kinase: Fyn, mTORC1, mTORC2, SGK1, PKA, PI3K, AKT, ERK
Phosphatase: PTPa, STEP
Small G protein: H-Ras, Rac1, RhoB
Guanine nucleotide exchange factor: GRF-1
Transcription factor: CREB
Scaffolding protein: RACK1
DMS: Dorsomedial striatum
DLS: Dorsolateral Striatum
NAc: Nucleus Accumbens
VTA: Ventral Tegmental Area
GO signaling pathways are activated by heavy alcohol use promoting
alcohol-drinking behaviors including excessive drinking, seeking, goal-directed behaviors, alcohol habit and relapse.
Not shown is mTOR signaling in the OFC (activated by heavy alcohol intake or alcohol prime) and CeA (activated by alcohol prime)
Green star depicts the NO GO signaling pathways that are activated by moderate alcohol intake limit alcohol drinking. Breakdown of the NO GO signaling pathways results in a transition of moderate to excessive and compulsive alcohol consumption and the development and/or maintenance of other alcohol-mediated behaviors.
Not shown is BDNF in the ventral hippocampus, and mPFC
alcohol-drinking behaviors including excessive drinking, seeking, goal-directed behaviors, alcohol habit and relapse.
Not shown is mTOR signaling in the OFC (activated by heavy alcohol intake or alcohol prime) and CeA (activated by alcohol prime)
Green star depicts the NO GO signaling pathways that are activated by moderate alcohol intake limit alcohol drinking. Breakdown of the NO GO signaling pathways results in a transition of moderate to excessive and compulsive alcohol consumption and the development and/or maintenance of other alcohol-mediated behaviors.
Not shown is BDNF in the ventral hippocampus, and mPFC
Contact Information
Mailing AddressDorit Ron, PhD
Box 0663 Department of Neurology University of California, San Francisco San Francisco, CA 94143-0663 Shipping Address675 Nelson Rising Lane, Rm 494
Sandler Neurosciences Building University of California, San Francisco San Francisco, CA 94158 |
Email: dorit.ron@ucsf.edu
Links |